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Registro Completo |
Biblioteca(s): |
Embrapa Amazônia Oriental. |
Data corrente: |
30/08/2017 |
Data da última atualização: |
22/12/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
FIDELIS, Q. C.; CASTRO, R. N.; GUILHON, G. M. S. P.; RODRIGUES, S. T.; SALLES, C. M. C. de; SALLES, J. B. de; CARVALHO, M. G. de. |
Afiliação: |
Queli C. Fidelis, Universidade Federal Rural do Rio de Janeiro; Rosane N. Castro, Universidade Federal Rural do Rio de Janeiro; Giselle M. S. P. Guilhon, UFPA; SILVANE TAVARES RODRIGUES, CPATU; Cristiane M. C. de Salles, Universidade Federal Rural do Rio de Janeiro; João B. de Salles, UEZO; Mario G. de Carvalho, Universidade Federal Rural do Rio de Janeiro. |
Título: |
Flavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents. |
Ano de publicação: |
2012 |
Fonte/Imprenta: |
Molecules, v. 17, n. 7, p. 7989-8000, 2012. |
Idioma: |
Inglês |
Conteúdo: |
The chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents. MenosThe chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75%... Mostrar Tudo |
Palavras-Chave: |
Agentes quimiopreventivos; Biflavonoides; Isoflavonas. |
Categoria do assunto: |
W Química e Física |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/163259/1/molecules-17-07989.pdf
|
Marc: |
LEADER 02407naa a2200229 a 4500 001 2074725 005 2021-12-22 008 2012 bl uuuu u00u1 u #d 100 1 $aFIDELIS, Q. C. 245 $aFlavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents.$h[electronic resource] 260 $c2012 520 $aThe chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents. 653 $aAgentes quimiopreventivos 653 $aBiflavonoides 653 $aIsoflavonas 700 1 $aCASTRO, R. N. 700 1 $aGUILHON, G. M. S. P. 700 1 $aRODRIGUES, S. T. 700 1 $aSALLES, C. M. C. de 700 1 $aSALLES, J. B. de 700 1 $aCARVALHO, M. G. de 773 $tMolecules$gv. 17, n. 7, p. 7989-8000, 2012.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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Registro Completo
Biblioteca(s): |
Embrapa Semiárido. |
Data corrente: |
28/02/2005 |
Data da última atualização: |
18/07/2022 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
LIMA, M. A. C. de; AZEVEDO, S. S. N.; SILVA, A. L. da; PAES, P. de C.; SANTOS, P. de S. |
Afiliação: |
MARIA AUXILIADORA COELHO DE LIMA, CPATSA. |
Título: |
Aplicação pós-colheita de 1-metilciclopropeno (1-MCP) em uva Superior Seedless. |
Ano de publicação: |
2005 |
Fonte/Imprenta: |
In: CONGRESSO IBERO-AMERICANO DE TECNOLOGIA PÓS-COLHEITA E AGROEXPORTAÇÃO, 4., 2005, Porto Alegre. Resumos... Porto Alegre: UFRGS; AITEP, 2005. |
Descrição Física: |
1 CD-ROM. |
Idioma: |
Português |
Conteúdo: |
O objetivo deste estudo foi avaliar a eficiência de tratamentos pós-colheita com 1-MCP na conservação da uva 'Superior Seedless'. |
Palavras-Chave: |
Inibidor de etileno; Uva sem semente. |
Thesagro: |
Conservação; Pós-Colheita; Qualidade; Tratamento; Uva. |
Thesaurus NAL: |
Grapes; Postharvest technology. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/CPATSA/31381/1/OPB30.pdf
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Marc: |
LEADER 00986nam a2200277 a 4500 001 1155540 005 2022-07-18 008 2005 bl uuuu u00u1 u #d 100 1 $aLIMA, M. A. C. de 245 $aAplicação pós-colheita de 1-metilciclopropeno (1-MCP) em uva Superior Seedless. 260 $aIn: CONGRESSO IBERO-AMERICANO DE TECNOLOGIA PÓS-COLHEITA E AGROEXPORTAÇÃO, 4., 2005, Porto Alegre. Resumos... Porto Alegre: UFRGS; AITEP$c2005 300 $c1 CD-ROM. 520 $aO objetivo deste estudo foi avaliar a eficiência de tratamentos pós-colheita com 1-MCP na conservação da uva 'Superior Seedless'. 650 $aGrapes 650 $aPostharvest technology 650 $aConservação 650 $aPós-Colheita 650 $aQualidade 650 $aTratamento 650 $aUva 653 $aInibidor de etileno 653 $aUva sem semente 700 1 $aAZEVEDO, S. S. N. 700 1 $aSILVA, A. L. da 700 1 $aPAES, P. de C. 700 1 $aSANTOS, P. de S.
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